Solid-Phase Synthesis and Cyclative Cleavage of Quorum Sensing Depsipeptide Analogues by Acylphenyldiazene Activation
- 20 February 2006
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2006 (4) , 0551-0554
- https://doi.org/10.1055/s-2006-932468
Abstract
Depsipeptide analogues of auto-inducing peptides (AIPs) from all four Staphylococcus aureus subgroups were prepared as panning reagents for in vitro antibody selection. Stepwise Fmoc solid-phase synthesis was used to prepare the linear precursors, which were cyclized without epimerization in a one-pot cleavage reaction following oxidation of the stable acylphenylhydrazine linkage to the reactive acylphenyldiazene.Keywords
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