Destruxin-A4 Chlorohydrin, a Novel Destruxin from Fungus OS-F68576: Isolation, Structure Determination, and Biological Activity as an Inducer of Erythropoietin
- 1 February 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (2) , 290-293
- https://doi.org/10.1021/np970475c
Abstract
In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2−2 μM.Keywords
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