Penicillin: Reversible Inhibition of Forespore Septum Development in Bacillus megaterium Cells
- 1 December 1974
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 6 (6) , 815-820
- https://doi.org/10.1128/aac.6.6.815
Abstract
Benzylpenicillin inhibits the development of the forespore septum in sporulating Bacillus megaterium cells. The inhibitory effect is a function of the duration of exposure to the antibiotic and is completely reversible by penicillinase. Under the incubation conditions employed, less than 20% of the covalently bound antibiotic is released from the cells. The penicillin which remains bound to the cells after treatment with penicillinase may be necessary but is not sufficient for the effect; unbound antibiotic in the sporulation medium is also required.Keywords
This publication has 16 references indexed in Scilit:
- Binding of Radioactive Benzylpenicillin to Asporogenous Mutants of Bacillus subtilis During Postexponential GrowthJournal of Bacteriology, 1973
- Five Penicillin-binding Components Occur in Bacillus subtilis MembranesJournal of Biological Chemistry, 1972
- Isolation by Covalent Affinity Chromatography of the Penicillin-Binding Components from Membranes of Bacillus subtilisProceedings of the National Academy of Sciences, 1972
- How penicillin kills bacteria: progress and problemsProceedings of the Royal Society of London. B. Biological Sciences, 1971
- Inactivation of D-Alanine Carboxypeptidase by Penicillins and Cephalosporins Is Not Lethal in Bacillus subtilisProceedings of the National Academy of Sciences, 1971
- Bacterial Sporulation as a Modified Procaryotic Cell DivisionNature, 1969
- TRACE METAL REQUIREMENTS FOR SPORULATION OF BACILLUS MEGATERIUMJournal of Bacteriology, 1964
- THE BINDING OF PENICILLIN IN RELATION TO ITS CYTOTOXIC ACTIONThe Journal of Experimental Medicine, 1954
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- The site of action of penicillin. 1. Uptake of penicillin on bacteriaBiochemical Journal, 1950