The ontogeny of L‐α‐hydroxyacid oxidase isozymes in the mouse

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Abstract
Mouse liver hydroxyacid oxidase isozymes are present at low levels at birth and increase inactivity until day 13 after which HAOX-B almost disappears and HAOX-A i s reduced to approximately one half the maximum level in the adult. Kidney HAOX-G appears near day 13 post partum and increases until adultl evels are reached, the female having four times the activity of the male. The pregnant female has significantly lower levels of HAOX-A and HAOX-B in the liver and higher activity ofHAOX-B in the kidney. Developmental changes occur in the extent of epigenetic modification of mouse liver HAOX-A during theearly neonatal period.

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