ADOPTIVE IMMUNOTHERAPY OF A GROSS VIRUS PRODUCING LYMPHOMA AND A METHYLCHOLANTHRENE-INDUCED FIBROSARCOMA IN TOLERANT RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (11) , 4039-4043
Abstract
Immunological tolerance to Gross virus-specific transplantation antigens in rats given neonatal injections of Gross virus (GV) was studied at the cellular level by the adoptive transfer of donor lymphoid cells beneath the kidney capsule of syngeneic recipient rats. Immune or normal donor cells invariably developed a cell-mediated immune reaction in kidneys of GV-tolerant recipients, presumably against GV antigens present on the surface of recipient lymphoid cells in the kidney. Spleen and lymph node cells from tolerant rats failed to develop a reaction in tolerant recipients, but developed a strong reaction to histoincompatible antigens in the kidneys of semisyngeneic tolerant rats. The immunologically tolerant state in the rats could be broken by adoptive transfer of spleen and lymph node cells from syngeneic rats immunized with GV-induced and also a GV-infected methylcholanthrene-induced fibrosarcoma growing in tolerant rats was successful when immune spleen and lymph node cells were administered i.p. 3 days after s.c. inoculation of 2 .times. 107 tumor cells in the case of the lymphoma, and 1 day after inoculation of 5 .times. 106 tumor cells in the case of the fibrosarcoma.

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