Ceftazidime in patients with pseudomonas infections
- 1 January 1983
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 12 (suppl A) , 161-169
- https://doi.org/10.1093/jac/12.suppl_a.161
Abstract
Ceftazidime was administered to 41 patients with serious infections caused by Pseudomonas aeruginosa (24 cases) and other bacteria (17 cases). The clinical response rate of pseudomonas infections (88%) was similar to that of other bacteria (94%) with microbiological eradication of 83% of initial pseudomonas isolates compared to 82% of non-pseudomonas strains. The development of resistance to ceftazidime during therapy was observed in 3 cases ( Enterobacter agglomerans, Enterobacter cloacae , and Ps. aeruginosa ), and superinfection by a resistant Enterobacter agglomerans occurred in one case. Adverse reactions of clinical significance included two cases of leukopenia and one case each of azotaemia, diarrhoea ( Clostridium difficile toxin positive), and rash.Keywords
This publication has 0 references indexed in Scilit: