For the past two years we have had under observation 2 patients with postarsphenamine dermatitis terminating in erythema, pigmentation, telangiectasia, atrophy and alopecia, a combination of symptoms which strikingly resembles those first described by Jacobi1at the German Dermatologic Congress in Berne in 1906 and named by him poikiloderma atrophicans vasculare. The body of literature on this subject is comparatively small, considering the fact that the disease has been known to the medical profession for thirty-five years. Since Jacobi's case approximately 160 others have been reported, most of them for confirmation of diagnosis before various local dermatologic societies. It is interesting to note that in only 4 of these cases was the poikiloderma or the poikiloderma-like changes in the skin regarded by the author as the sequels of a postarsphenamine dermatitis; these 4 all appeared in the foreign literature. REVIEW OF THE LITERATURE K. Pinter2reported the first