CUTANEOUS LEISHMANIASIS (ORIENTAL SORE)
- 1 June 1944
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology and Syphilology
- Vol. 49 (6) , 433-435
- https://doi.org/10.1001/archderm.1944.01510120047012
Abstract
Vaccination against oriental sore by the intracutaneous inoculation of living cultures of Leishmania tropica, advocated by Lawrow and Dubowskoj (1937),1by Berberian (1939),2by Senekji and Beattie (1941)3and by Katzenellenbogen (1942,4may now be considered as an accepted procedure. Persons who are vaccinated or wish to be vaccinated often ask the question, "When shall we be sufficiently immune against oriental sore to escape infection by natural routes?" To answer this question correctly, I have carried out a number of reinoculations on volunteer subjects at different stages of development of their experimental sores. EXPERIMENTAL STUDIES N.N.N. slope cultures of L. tropica were used for all inoculations. The site of inoculation was the anterior aspect of the thigh, about 15 cm. above the kneecap. All inoculations were strictly intracutaneous. The volume of the inoculum was always 0.2 cc. and represented approximately 500,000Keywords
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