The growth of cultured human foreskin keratinocytes is not stimulated by a tumor promoter
- 31 December 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (1) , 109-112
- https://doi.org/10.1093/carcin/5.1.109
Abstract
The tumor promoter 12-0-tetmlecanoyl phorbol-13-acetate (TPA) does not stimulate the growth of human epidermal cells in foreskin explant cultures; a dosedependent inhibition is seen at doses higher than 10 -5 µg/ml . TPA also inhibits epidermal growth factor-stimulated growth and does not induce ornithine decarboxylase activity or increase potyamine levels. This is not due to the rapid breakdown of TPA, since TPA is not metabolized to any appredable extent.This publication has 4 references indexed in Scilit:
- PHORBOL DIESTER AND EPIDERMAL GROWTH-FACTOR RECEPTORS IN 12-O-TETRADECANOYLPHORBOL-13-ACETATE-RESISTANT AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE-SENSITIVE MOUSE EPIDERMAL-CELLS1982
- Mechanism of synergistic induction of DNA synthesis by epidermal growth factor and tumor promotersJournal of Cellular Physiology, 1981
- Inhibition of phorbol ester-induced polyamine accumulation in mouse epidermis by anti-inflammatory steroidBiochemical and Biophysical Research Communications, 1979
- Inhibition of epidermal growth factor binding to surface receptors by tumor promotorsBiochemical and Biophysical Research Communications, 1979