Serotonin Enhances Striatal Dopamine Outflow In Vivo Through Dopamine Uptake Sites

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Abstract
Serotonin (5‐HT) administered at 1, 3, and 10 µM into the striatum of halothane‐anesthetized rats by in vivo microdialysis increased extracellular dopamine (DA) in a concentration‐dependent manner (approximately 65, 190, and 440%, respectively). These effects were reduced by 50% in the presence of 1 µM tetrodotoxin (TTX) or in the absence of Ca2+ ions. The DA uptake blocker nomifensine (0.1 µM) significantly lowered (by 50%) the enhancement of DA outflow induced by 3 µM 5‐HT. Nomifensine (1 µM) coperfused with 1 µM TTX abolished the 1 and 3 µM 5‐HT‐induced DA outflow, whereas the effect of 10 µM 5‐HT was significantly reduced by 1 (−55%) and 10 µM (−70%) nomifensine. These data demonstrate that, in vivo, striatal DA uptake sites are partially involved in the DA‐releasing action of 5‐HT.

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