In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography
Open Access
- 1 January 2004
- journal article
- research article
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 9 (1) , 121-125
- https://doi.org/10.1117/1.1627774
Abstract
Glaucoma causes damage of the nerve fiber layer, which may cause loss of retinal birefringence. Therefore, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, coregistered with retinal video images of the location of PS-OCT scans. Preliminary measurements of a healthy volunteer show that the double-pass phase retardation per unit of depth of the RNFL is not constant and varies with location, with values between 0.18 and 0.37 deg/μm. A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions. © 2004 Society of Photo-Optical Instrumentation Engineers.Keywords
This publication has 16 references indexed in Scilit:
- Enhanced Visualization of Macular Pathology With the Use of Ultrahigh-Resolution Optical Coherence TomographyArchives of Ophthalmology (1950), 2003
- In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomographyOptics Letters, 2002
- Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomographyOptics Letters, 2002
- In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomographyJournal of Biomedical Optics, 2001
- High-speed fiber–based polarization-sensitive optical coherence tomography of in vivo human skinOptics Letters, 2000
- Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomographyOptics Letters, 1999
- Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomographyOptics Letters, 1997
- Quantification of Nerve Fiber Layer Thickness in Normal and Glaucomatous Eyes Using Optical Coherence TomographyArchives of Ophthalmology (1950), 1995
- Histopathologic Validation of Fourier-Ellipsometry Measurements of Retinal Nerve Fiber Layer ThicknessArchives of Ophthalmology (1950), 1990
- Optic Nerve Damage in Human GlaucomaArchives of Ophthalmology (1950), 1982