Systemic Phosphate Influences on Dental Caries in the NMRI-D Rat

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Abstract
Under standardized experimental conditions which produce only pit-fissure caries, daily gastric intubation of pH 7 phosphate buffer in amounts equivalent to the P consumption of control rats on the cariogenic basal purified diet supplemented with 1.5% or 3.0% Na2HPO4 showed no cariostatic influence of systemic phosphate after 35 days. The dietary phosphate rats showed significant cariostasis compared to the control animals on nonsupplemented diet. The cariostatic effect of phosphate on pit-fissure caries depends on direct local action of phosphate acquired from the diet.