Penicillamine-induced polymyositis with complete heart block
- 1 November 1989
- journal article
- case report
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 10 (11) , 1041-1044
- https://doi.org/10.1093/oxfordjournals.eurheartj.a059417
Abstract
Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis. After drug withdrawal the muscle enzymes and the cardiac rhythm gradually normalized, only leaving a right bundle branch block. Although this is the first report to show that severe cardiac damage associated with penicillamine-induced polymyositis is a potentially reversible condition, the severity of the three cases reported so far warrants close observation for cardiac involvement in patients with penicillamine-induced polymyositis.Keywords
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