The molecular basis for public T-cell responses?
Top Cited Papers
- 1 March 2008
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 8 (3) , 231-238
- https://doi.org/10.1038/nri2260
Abstract
Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are observed to dominate the response to the same antigenic epitope in multiple individuals, have long been a focus of immune T-cell repertoire studies. However, the mechanism that enables the survival of a specific TCR from the diverse repertoire produced in the thymus through to its involvement in a public immune response remains unclear. In this Opinion article, we propose that the frequency of production of T cells bearing different TCRs during recombination has an important role in the sharing of TCRs in an immune response, with variable levels of 'convergent recombination' driving production frequencies.Keywords
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