Specific Epidermal Growth Factor Receptors on Porcine and Human Thyroid Membranes
- 1 November 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 17 (11) , 592-594
- https://doi.org/10.1055/s-2007-1013614
Abstract
Specific, high affinity, saturable receptors for epidermal growth factor (EGF) have been demonstrated both on porcine and on human thyroid membranes. The binding affinities of porcine (Ka 3.0 × 10-9 M) and human thyroid EGF receptors (Ka 1.75 × 10-9 M) are very similar. TSH does not inhibit the binding of 125I-EGF to either membrane. These results suggest the possibility that EGF may be involved in the regulation of human as well as porcine thyroid follicular cell growth and function.Keywords
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