EXPERIMENTAL VACCINATION AGAINST MEASLES

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Abstract
The antigenicity and safety of modified live virus measles vaccine was studied in monkeys and in two children. None of the monkeys inoculated orally, intramuscularly, or intercerebrally showed signs of disease, and all produced antibodies. Two children inoculated with the vaccine had a good immunologic response but developed a mild illness with fever, sore throat, and some leukopenia. Distemper virus, believed to be antigenically related to measles virus, was also tested by intramuscular and intercerebral inoculation into susceptible monkeys. No signs of illness were observed, and all monkeys tested developed antibodies against distemper. None produced measles-neutralizing antibodies even after two injections of distemper virus. It would appear that the strain of distemper virus used in these experiments lacked the antigenic component which would cause significant measles antibody production.

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