Pharmacokinetics of ribavirin in patients with hepatitis C virus

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Abstract
Aim: A population pharmacokinetic analysis was performed using plasma concentration data (n = 7025) from 380 patients to examine the relationship between ribavirin dose and its pharmacokinetics.Methods: Ribavirin pharmacokinetics were described by a three‐compartment model with sequential zero‐order and a first‐order absorption processes. Interoccasion variability and food effects were included.Results: Lean body weight (range 41–91 kg) was the only covariate with a clinically significant influence on ribavirin pharmacokinetics, affecting clearance (15.3–23.9 l h−1) and the volume of the larger peripheral compartment.Conclusion: The model provided a good description of the available data, confirmed by accurate estimates of parameter values and low residual variability (17%).

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