Serological abnormalities in juvenile chronic arthritis: a review of 46 cases.

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Abstract
Children (46) with juvenile chronic arthritis [JCA], were evaluated. All were under 16 yr. Patients with juvenile ankylosing spondylitis, psoriatic arthritis and arthritis associated with inflammatory bowel disease were excluded. Patients (26) had pauciarticular, 9 had systemic, 8 had polyarticular and 3 had seropositive adult type JCA. In all patient groups Ig[immunoglobulin]G, IgM, IgA and complement component C3 levels were significantly higher than in the control group. None of the controls, but 13 of 46 patients had high IgE levels. IgA and IgG values were significantly higher in the seropositive subgroup than in the pauciarticular subgroup. There was no other positive correlation between levels of Ig, C3 and clinical features of disease. Platelet counts were significantly higher in patients wilh active disease. In the control group 4 of 10 children had hidden rheumatoid factor. All children with positive findings were young.