EFFECT OF PRIOR THIRD-PARTY BLOOD TRANSFUSIONS ON CANINE RENAL ALLOGRAFT SURVIVAL

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Abstract
The relationships between immune reactivity after blood transfusions, subsequent kidney allograft survival and donor selection were studied in dogs. Animals with a high and low serological immune reactivity toward antigens contained in blood transfusion were observed. Genetic control of this reactivity or a linkage of this property to DLA, sex or red blood cell markers inheritance was not apparent in the 4 beagle families studied. The 2 recipients with the lowest immune reactivity scores were also the longest survivors after a DLA-mismatched kidney graft. Seven other recipients with higher scores rejected their DLA-mismatched kidneys as rapidly as did untransfused animals. Kidney graft survival was decreased in some recipients of DLA-identical kidneys (n = 5), presumably through sensitization for minor histocompatibility antigens. A normal or an increased survival time of DLA-identical kidneys was found in the remaining animals (n = 6). Most of these recipients appeared to have a higher than average reactivity in 2-stage microcytotoxicity testing. This might have been attributable to the presence of enhancing antibodies. Further studies in preclinical animal models are needed to define the optimal transfusion policy for human patients awaiting a kidney graft.

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