X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?
- 1 January 1996
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 118 (25) , 5857-5861
- https://doi.org/10.1021/ja954328h
Abstract
No abstract availableThis publication has 31 references indexed in Scilit:
- Rapamycin: A novel immunosuppressive macrolideMedicinal Research Reviews, 1994
- A Nonimmunosuppressive Triene-Modified Rapamycin Analog Is a Potent Inhibitor of Peptidyl Prolyl cis-trans-IsomeraseBiochemical and Biophysical Research Communications, 1993
- Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and RapamycinJournal of Molecular Biology, 1993
- The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.The Journal of Experimental Medicine, 1992
- Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationNature, 1992
- FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurinNature, 1992
- Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.Proceedings of the National Academy of Sciences, 1990
- A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilinNature, 1989
- Unsaturated carbenes from primary vinyl triflates. 6. Competitive addition of isopropylidenecarbene to olefinsThe Journal of Organic Chemistry, 1977
- Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.The Journal of Antibiotics, 1975