EXPOSURE TO LONG WAVELENGTH ULTRAVIOLET RADIATION DECREASES PROCESSING OF LOW DENSITY LIPOPROTEIN BY CULTURED HUMAN FIBROBLASTS

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Abstract
Exposure of MRC5 human fibroblasts to UVA radiation (365 nm) resulted in a dose‐dependent decrease in low density lipoprotein (LDL) uptake and degradation by cells. Following a 25 J/cm2 irradiation dose, about 45% and 70% reduction in 125I‐LDL uptake and degradation were observed, respectively. Under the same conditions, the 14C‐sucrose uptake was also decreased to about the same extent as LDL uptake. Cell pretreatment with the antioxidants vitamin E and vitamin C did not prevent the UVA‐induced fall in LDL degradation. These results point to the possible effects of UVA radiation on receptor‐mediated and nonspecific uptake of exogenous molecules. With special regard to the alterations in receptor‐mediated processing of exogenous ligands, such a phenomenon could be of importance in UVA‐induced skin degenerative processes.

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