Reproductive Tract Lesions in Male Mice Exposed Prenatally to Diethylstilbestrol
- 5 December 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4218) , 991-992
- https://doi.org/10.1126/science.242076
Abstract
Sixty percent of the male offspring from pregnant mice treated with diethylstilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal or fibrotic testes, or both. Additionally, nodular masses in the ampullary region of the reproductive tract were observed in 6 of 24 animals; one of these appeared to be preneoplastic.Keywords
This publication has 12 references indexed in Scilit:
- Prenatal Exposure to StilbestrolNew England Journal of Medicine, 1975
- Cervicovaginal epithelium: Its origin and developmentAmerican Journal of Obstetrics and Gynecology, 1973
- Clear-Cell Adenocarcinoma of the Genital Tract in Young FemalesNew England Journal of Medicine, 1972
- Estrogen, vaginal cancer, and vaginal developmentAmerican Journal of Obstetrics and Gynecology, 1972
- Vaginal Cancer after Maternal Treatment with Synthetic EstrogensNew England Journal of Medicine, 1971
- Adenocarcinoma of the VaginaNew England Journal of Medicine, 1971
- Metaplasia in male rat reproductive accessory glands induced by neonatal estrogen treatmentCellular and Molecular Life Sciences, 1968
- Male PseudohermaphrodismNew England Journal of Medicine, 1959
- Experimental intersexuality. The effects of estrogens on the antenatal sexual development of the ratJournal of Anatomy, 1940
- Pathological Conditions Induced by Oestrogenic Compounds in the Coagulating Gland and Prostate of the MouseThe American Journal of Cancer, 1935