Heterotrimeric G protein activation by G-protein-coupled receptors
Top Cited Papers
- 1 January 2008
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 9 (1) , 60-71
- https://doi.org/10.1038/nrm2299
Abstract
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.Keywords
This publication has 156 references indexed in Scilit:
- Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interactionProceedings of the National Academy of Sciences, 2007
- Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteinsProceedings of the National Academy of Sciences, 2007
- A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G proteinProceedings of the National Academy of Sciences, 2007
- RETRACTED: Structural basis for nucleotide exchange on Gαisubunits and receptor coupling specificityProceedings of the National Academy of Sciences, 2007
- Some G protein heterotrimers physically dissociate in living cellsProceedings of the National Academy of Sciences, 2006
- Crystal structure of a photoactivated deprotonated intermediate of rhodopsinProceedings of the National Academy of Sciences, 2006
- Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathwayProceedings of the National Academy of Sciences, 2006
- The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal StructureJournal of Molecular Biology, 2004
- Probing the mechanism of rhodopsin-catalyzed transducin activationJournal of Neurochemistry, 2001
- The N-terminal Extension of Gαq Is Critical for Constraining the Selectivity of Receptor CouplingJournal of Biological Chemistry, 1997