Effect of Glucagon (HGF) on Deposition of Muscle Glycogen

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Abstract
The specific activity of muscle and liver glycogen was determined after administration of C14 labeled glucose and insulin or insulin and glucagon to pancreatectomized dogs. There was a significant decrease in glycogen formation of muscle and liver when glucagon was added to the insulin. Glucagon has a significant peripheral action in that it decreased muscle glycogen formed when insulin is given.