CEREBRAL ENERGY-METABOLISM AND COMPUTERIZED EEG - ANALYSIS FOLLOWING TRANSIENT ISCHEMIA IN THE RAT

  • 1 January 1982
    • journal article
    • research article
    • Vol. 13  (4) , 553-563
Abstract
Cerebral energy metabolism and EEG power spectra were evaluated before, during and after 1 min of global compression ischemia induced in N2O anesthetized rats. Before ischemia, the EEG of rats was characterized by theta and delta frequencies. During ischemia, the EEG flattened after 14 .+-. 1 s and the electrical activity reappeared 55 .+-. 4 s after recirculation and was characterized by high amplitude slow waves. After ischemia, the total power showed a rapid rebound mainly due to a 10 fold increase of delta band. Ten min after recirculation, the EEG was normal. The ischemia induced a decrease of phosphocreatine, ATP and glucose, and an increase of ADP, AMP and lactate, while pyruvate remained normal. During recirculation phosphocreatine, ATP, glucose and energy charge potential showed a rapid recovery. AMP normalized after 10 min, while ADP was slightly higher for up to 30 min. Lactate returned to normal levels after 30 min and pyruvate showed a high peak at 3 min and returned to normal values after 30 min. Evidently there is no correlation between EEG and the metabolic pattern of recovery after a short complete ischemia.