Characterization of cDNA clones encoding two putative isoforms of the α1 subunit of the dihydropyridine‐sensitive voltage‐dependent calcium channel isolated from rat brain and rat aorta
- 3 July 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 250 (2) , 386-388
- https://doi.org/10.1016/0014-5793(89)80761-6
Abstract
CDNA clones encoding rat brain and rat aorta isoforms of the α1 subunit of the dihydropyridine-sensitive, voltage-dependent calcium channel were isolated and sequenced. These tissue-specific cDNA clones share significant amino acid similarity with the rabbit skeletal muscle calcium channel α1 subunit (75% and 66% amino acid identity for rat brain and rat aorta isoforms, respectively). Northern analysis revealed transcript sizes of 6.5 and 8.6 kb in aorta and 8.6 kb in brain.Keywords
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