G-6-PD Manchester: A New Variant Associated With Chronic Nonspherocytic Hemolytic Anemia
Open Access
- 1 February 1974
- journal article
- Published by American Society of Hematology in Blood
- Vol. 43 (2) , 271-276
- https://doi.org/10.1182/blood.v43.2.271.271
Abstract
A variant of glucose-6-phosphate dehydrogenase (G-6-PD) designated G-6-PD Manchester, and associated with chronic nonspherocytic hemolytic anemia, was found in an English male. The electrophoretic mobility at pH 7.0 of this G-6-PD variant is the slowest yet described. Substrate specificity is normal but enzyme activity is markedly inhibited by NADPH, and this is thought to account for the severe chronic hemolysis.Keywords
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