Pattern and chance in the use of the genetic code
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 10 (4) , 319-323
- https://doi.org/10.1007/bf01734221
Abstract
The use of triplet code words inE. coli,ФX174, MS2, and rabbit globin was examined. A significant deficiency of purines in the third position of fourfold degenerate codons was noted, although its significance is not understood. There has been no consistent selection against uracil in pyrimidine restricted codons. For many amino acids the choice between code words appears random, while for arginine, isoleucine, and probably glycine, distinct biases exist which can be explained in terms of tRNA availability.This publication has 12 references indexed in Scilit:
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