"N-NITROSO-BIS(2-ACETOXYPROPYL)AMINE AS A FURTHER PANCREATIC CARCINOGEN IN SYRIAN GOLDEN-HAMSTERS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (8) , 2877-2884
Abstract
N-nitroso-bis(2-acetoxypropyl)amine, a possible .beta. metabolite of N-nitro-di-n-propylamine, was a potent carcinogen in the Syrian golden hamster. After a single s.c. treatment, the pancreas was the most affected organ, followed by the liver, respiratory tract and kidneys. However, repeated application resulted in a higher incidence of neoplasms of the respiratory tract than of the pancreas and kidneys. The effect of N-nitroso-bis(2-acetoxypropyl)amine on toxicity, target tissues and carcinogenicity was similar to that of N-nitroso-bis(2-hydroxypropyl)amine. The assumption that these 2 compounds may have similar metabolic pathways was confirmed; N-nitroso-bis(2-acetoxypropyl)amine was readily deesterified to N-nitroso-bis(2-hydroxypropyl)amine in vivo and in vitro.

This publication has 0 references indexed in Scilit: