The detection of gene mutation in transgenic mice (MutaTMMouse) following a single oral dose of 2-acetylaminofluorene
- 1 March 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 10 (2) , 149-150
- https://doi.org/10.1093/mutage/10.2.149
Abstract
Transgenic mouse assays, such as MutaTMMouse, provide a method to predict the potential target organ carcinogenicity of chemical compounds. As part of a validation study, 2-acetylaminofluorene was administered as a single oral dose of either 50 or 100 mg/kg. The mice were killed 3, 7, 14, 28, 56 or 112 days after this single treatment. Mutation frequencies were determined in liver DNA. The results showed that a mutagenic response was observed in the mice treated at the highest dose (100 mg/kg) and this increase was expressed from 28 up to 112 days after the single exposure.Keywords
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