Fish are like flies are like frogs: Conservation of dorsal‐ventral patterning mechanisms
- 1 April 1997
- Vol. 19 (4) , 281-284
- https://doi.org/10.1002/bies.950190404
Abstract
Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor‐β family member dpp patterns the embryonic dorsalventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp‐4, the dpp homolog, in patterning the dorsalventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl, that disrupt dorsal‐ventral patterning in the zebrafish Danio rerio(1). Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsalventral patterning in a vertebrate.Keywords
This publication has 31 references indexed in Scilit:
- The vertebrate organizer: structure and moleculesTrends in Genetics, 1996
- The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm.Genes & Development, 1996
- Conservation of dorsal-ventral patterning in arthropods and chordatesCurrent Opinion in Genetics & Development, 1996
- The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4Cell, 1996
- Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.Genes & Development, 1995
- A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordinNature, 1995
- Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.Genes & Development, 1994
- Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivoCell, 1994
- decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryoCell, 1992
- The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.Genes & Development, 1987