AMINO NITRILES: III. REACTION OF AMINO NITRILES WITH ISOTHIURONIUM SALTS
- 1 January 1962
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 40 (1) , 143-150
- https://doi.org/10.1139/v62-021
Abstract
N-Substituted-N′,N″-di-(2-cyanoethyl)-guanidines have been cyclized with the elimination of acrylonitrile to 2-imino-3-substituted-4-keto-hexahydropyrimidines. These pyrimidine derivatives also were prepared by treating 1-substituted-3-(2-cyanoethyl)-S-methyl isothiuronium iodide salts with ammonia. 1-(3,4-Dichlorobenzyl)-3-(2-cyanoethyl)-urea was cyclized in the presence of absolute ethanolic hydrogen chloride to 2,4-diketo-3-(3,4-dichloro-benzyl)-hexahydropyrimidine.Keywords
This publication has 1 reference indexed in Scilit:
- Amino Nitriles. I. Cyclization of α-CyanoalkylureasJournal of the American Chemical Society, 1958