CHANGES IN TOTAL NUMBER OF NEUROGLIA, MITOTIC CELLS AND NECROTIC CELLS IN ANTERIOR LIMB OF MOUSE ANTERIOR COMMISSURE FOLLOWING HYPOXIC STRESS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 122  (NOV) , 447-453
Abstract
The effects of hypoxic stress (390 mmHg) on the total number of glia, cell division and cell death in the anterior limb of the anterior commissure were studied. There was a significant (P < 0.01) fall in the total number of glia following exposure to hypoxia at 390 mmHg for 2 days. No significant change was observed in the total number of glia between the hypoxic and recovery group 1 wk after return to sea level (about 760 mmHg). No change was observed in the number of mitotic figures in the control, hypoxic or recovery groups, but significant decreases were observed in the mean number of necrotic cells between both the control and hypoxic groups (P < 0.05) and the hypoxic and recovery groups (P < 0.012). The decrease in necrotic cells may be due to a large number of elderly and effete cells, which would normally have undergone degeneration over a period of weeks, dying rapidly after the onset of hypoxia, thus temporarily reducing the daily cell death rate.