NEUROENDOCRINE PACEMAKER FOR GROWTH, DEVELOPMENT AND AGEING
- 1 May 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Age and Ageing
- Vol. 11 (2) , 73-88
- https://doi.org/10.1093/ageing/11.2.73
Abstract
The hypothesis is formulated that ageing is mediated through alteration in a pacemaker system located in the hypothalamus and dependent on serotonin-thyroid hormone interactions. Data in support of this hypothesis include: imbalance in central nervous system (CNS) neurotransmitters with ageing, with serotonin dominance; impairment of hypothalamic neurosecretion; increased heterogeneity of thyrotropin forms secreted from the aged pituitary; and drug and dietary manipulation of CNS serotonin with consequent effects on endocrine function and homocostasis.Keywords
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