Structural Basis of the A14 and A15 Allotypic Specificities in Rabbit Immunoglobulin G
- 1 June 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (6) , 1341-1345
- https://doi.org/10.1073/pnas.68.6.1341
Abstract
The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the Cγ2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the Cγ2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human γ chains is apparent (about 60-80%).Keywords
This publication has 22 references indexed in Scilit:
- Genetic Control of Variable and Constant Regions of Immunoglobulin Heavy ChainsNature New Biology, 1971
- Somatic Translocation of Antibody GenesNature, 1970
- Molecular determinants of the A11 and A12 allotypic specificities in rabbit immunoglobulinBiochemistry, 1969
- Analysis of Amino Acid Phenylthiohydantoins by Gas ChromatographyJournal of Biological Chemistry, 1969
- Immunochemistry and genetics of a "new" allotypic specificity Ae14 of rabbit gamma-G immunoglobulins: recombination in somatic cells.1969
- GENETICS OF IMMUNOGLOBULIN κ-CHAINS: CHEMICAL ANALYSIS OF NORMAL HUMAN LIGHT CHAINS OF DIFFERING INV TYPESProceedings of the National Academy of Sciences, 1969
- [Heterogeneity of the immunoglobulins as revealed by their 3 kinds of antigenic specificity: isotypic, allotypic and idiotypic].1968
- Allotypy of Rabbit Immunoglobulin: an Agglutinating SpecificityVox Sanguinis, 1968
- Allotypy in rabbit 19S proteinBiochemical and Biophysical Research Communications, 1963
- STRUCTURE OF HUMAN HEMOGLOBIN .3. SEQUENCE OF AMINO ACIDS IN TRYPTIC PEPTIDES OF ALPHA CHAIN1962