Gene targeting in mice as a strategy for understanding lipid metabolism and atherogenesis

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Abstract
Gene targeting in pluripotent mouse embryonic stem cells allows us to introduce alterations into specific genes in the genome of mice and to study the consequence of the alterations in the whole animal. It is a particularly powerful tool for unravelling the complex etiology of multifactorial diseases such as dyslipoproteinemia and atherosclerosis, in which environmental factors have a strong influence. Modification of genes involved in lipid metabolism, and studying the consequences in mice of single mutations and combinations of mutations, have great promise for increasing our understanding of lipid metabolism and atherogenesis.

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