Antineoplastic Diterpene−Benzoate Macrolides from the Fijian Red Alga Callophycus serratus
- 12 October 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (23) , 5261-5264
- https://doi.org/10.1021/ol052121f
Abstract
Three diterpene−benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.Keywords
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