Markers for Detection of Supplementation in Narcotic Programs—Deuterium-Labeled Methadone
- 6 August 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 193 (4252) , 498-500
- https://doi.org/10.1126/science.941022
Abstract
Specific deuterium labeling of methadone and use of gas chromatography-mass spectroscopy technique permits rapid and quanitative determination of the ratio of the labeled to unlabeled drug in body fluids. A trideuertiomethadone (methadone-d3) was shown to have exactly the same analgesic activity and toxicity in mice as methadone. The rates of absorption, distribution, and excretion of methadone-d3 and methadone were identical in rats. These observations suggest that methadone-d3 may be used as an in vivo marker for monitoring methadone intake of patients, and thus may improve the effectiveness of methadone treatment programs.This publication has 4 references indexed in Scilit:
- The Search for a Better AnalgesicScience, 1973
- Medical Safety and Side Effects of Methadone in Tolerant IndividualsPublished by American Medical Association (AMA) ,1973
- A New Synthesis and Confirmation of the Structure of Amidone1Journal of the American Chemical Society, 1947