Effects of Intravenous Phospholipid on Low Density Lipoprotein Turnover in Man

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Abstract
The mechanism of the rise in plasma low density lipoprotein (LD) levels following i.v. administration of a triglyceride-phospholipid emulsion (Intralipid) was studied by measuring LDL turnover in 8 healthy subjects. The plasma half-life, and the absolute and fractional catabolic rates of LDL protein (apo-LDL) were unaffected by intragastric Intralipid; apo-LDL half-life was prolonged and its fractional catabolic rate was decreased by i.v. Intralipid. Similar changes were observed after i.v. administration of the egg phospholipid constituent of Intralipid. Accompanying increases in the oleate: linoleate ratio of both high and low density lipoprotein cholesterol esters were secondary to phospholipid exchange between infused and endogenous lecithin. The increased concentration of LDL in plasma following i.v. administration of egg phospholipid-containing emulsions was due, at least in part, to a decrease in the fractional catabolic rate of apo-LDL. A possible relationship between apo-LDL catabolism and the fatty acid composition of LDL is suggested.