Absence of genetic heterogeneity in Duchenne muscular dystrophy shown by a linkage study using two cloned DNA sequences.
Open Access
- 1 August 1983
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 20 (4) , 249-251
- https://doi.org/10.1136/jmg.20.4.249
Abstract
A linkage study using two different restriction fragment length polymorphisms (RFLPs) identified with cloned DNA sequences has failed to provide evidence for genetic heterogeneity in Duchenne muscular dystrophy (DMD) when tested against intelligence quotient (IQ). Analysis of data for age of confinement to a wheelchair against IQ gave no evidence for heterogeneity. These results are of a practical as well as theoretical significance, since the existence of multiple loci causing DMD would make it more difficult to apply linkage data to genotype prediction in this disease.This publication has 9 references indexed in Scilit:
- The use of linked DNA polymorphisms for genotype prediction in families with Duchenne muscular dystrophy.Journal of Medical Genetics, 1983
- Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosomeNucleic Acids Research, 1983
- Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophyNature, 1982
- CLINICAL FEATURES AND CLASSIFICATION OF THE MUSCULAR DYSTROPHIESBritish Medical Bulletin, 1980
- A study of possible heterogeneity in Duchenne muscular dystrophyClinical Genetics, 1979
- Linkage between the loci for benign (Becker-type) X-borne muscular dystrophy and deutan colour blindnessJournal of Medical Genetics, 1974
- The Genetic Relationship of Progressive Muscular Dystrophy (Duchenne Type) and Mental RetardationDevelopmental Medicine and Child Neurology, 1968
- INTELLECTUAL FUNCTION IN CHILDHOOD PROGRESSIVE MUSCULAR DYSTROPHYPediatrics, 1962