INFLUENCE OF 6-HYDROXYDOPAMINE AND 6-HYDROXYDOPA ON THE PHOSPHOLIPIDS CONTENT IN THE BRAIN OF RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 27  (3) , 325-328
Abstract
6-Hydroxydopamine and 6-hydroxydopa injected i.p. in a dose of 50 .mu.g/g in newborn rats, 2 and 6 wk old caused a drop in content of phosphatidylcholine and phosphatidylserine, and an increase in content of phosphatidylinositol in the brains of 2 wk old rats treated with 6-hydroxydopamine in comparison with controls. 6-Hydroxydopa administration caused an increase of the content of phosphatidylcholine and phosphatidylinositol and decrease of diphosphatidylglycerol in the brain of 2 wk old rats. In the brains of 6 wk old rats only a decrease in content of phosphatidic acid was observed after administration of either 6-hydroxydopamine or 6-hydroxydopa. The results are further evidence of a nonspecific toxic action of both compounds.

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