Resolution and Absolute Configuration of 1-Ethyl-2-propynylamine and 1-Propyl-2-propynylamine.

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Abstract
1-Ethyl-2-propynylamine and 1-propyl-2-propynylamine were resolved, and the absolute configurations of the enantiomers were established by correlation to D-(.sbd.)-2-aminobutyric acid and D-(.sbd.)-norvaline, respectively. [The enantiomers of some N-(4-tert-amino-1-methyl-2-butynyl)-substituted succinimides and 2-pyrrolidones show strong stereospecificity in blocking the motor effects of the muscarinic agent oxotremorine, N-(4-pyrrolidino-2-butylnyl)-2-pyrrolidone, and that the pharmacological effect is exerted mainly by the (R)-(+)-isomers.].

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