Effect of Cimetidine on Gastric Mucus Glycoprotein Biosynthesis
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 34 (2) , 122-126
- https://doi.org/10.1159/000199320
Abstract
The effects of cimetidine on gastric mucus glycoprotein biosynthesis in rat gastric mucosa were investigated using organ culture technique. 2 h following oral administration of cimetidine (40 mg/kg body weight), corpus tissue was placed in the organ culture. Mucus glycoprotein synthesis was accelerated to 137% of control (p < 0.01). In order to investigate the direct effect of cimetidine on mucus glycoprotein biosynthesis, corpus tissue was cultured in the medium containing cimetidine. 100 μM cimetidine enhanced mucus glycoprotein biosynthesis to 174% (p < 0.01). Cimetidine was found to stimulate gastric mucus glycoprotein biosynthesis both in vivo and in vitro.Keywords
This publication has 8 references indexed in Scilit:
- Sulfated Glycoprotein Biosynthesis in Human Gastric Mucosal BiopsiesDigestion, 1984
- The site of sulfated glycoprotein biosynthesis in rat gastric mucosaComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1983
- Distribution of mucosal macromolecular glycoproteins in rat stomachComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1982
- Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats.Gut, 1980
- Bioavailability and pharmacokinetics of cimetidineEuropean Journal of Clinical Pharmacology, 1979
- TOPICAL ASPIRIN PLUS HCL GASTRIC LESIONS IN THE RAT - CYTOPROTECTIVE EFFECT OF PROSTAGLANDIN, CIMETIDINE, AND PROBANTHINE1979
- Cimetidine and prostaglandin: Evidence for different modes of action on the rat gastric mucosaGastroenterology, 1978
- Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcersDigestive Diseases and Sciences, 1977