Control over absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry in the synthesis of allylically substituted alkenes from diphenylphosphinoyl epoxy alcohols
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 15,p. 1913-1934
- https://doi.org/10.1039/p19950001913
Abstract
Regioselective ring-openings of epoxy alcohols bearing a diphenylphosphinoyl ( Ph2PO ) group give diols which can undergo stereospecific Horner–Wittig elimination. This method was used to make allylic alcohols, unsaturated β-hydroxy sulfides, homoallylic alcohols and unsaturated amino acids, with control over their absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry.Keywords
This publication has 0 references indexed in Scilit: