Response of Human Aldosteronoma Cells in Culture to the N-Terminal Glycopeptide of Pro-Opiomelanocortin and γ3-MSH

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Abstract
Cells were isolated from one of two adenomas from the adrenal cortex of a hypertensive patient with primary hyperaldosteronism. A primary culture of these cells responded with increased aldosterone secretion to γ3-MSH and human (residues 1-76) and porcine (residues 1-80) N-terminal peptides of pro-opiomelanocortin (POMC). EC50 was lowest for γ3-MSH, while maximal response was greater for both N-terminal peptides of POMC. We conclude that γ3-MSH derived from the N-terminal segment of POMC contains the active core of the aldosterone-stimulating activity of the N-terminal on these adrenal cells.

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