Gastric Acid Secretion in Gastric Fistula Cats during Reserpine Treatment1

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Abstract
The effect of daily intramuscular injections of reserpine on basal gastric secretion and on the secretory responses to intravenous histamine, gastrin, metha‐choline, and insulin hypoglycemia, was investigated in nonanesthetized gastric fistula cats. Reserpine treatment during 3 days or more produced an elevation of basal secretion, and the secretory responses to histamine and gastrin were increased, while that to methacholine remained unaltered and that to insulin hypoglycemia was reduced. The changes described were highly significant. The results suggest at least a two‐fold mode of action of reserpine on the gastric secretory mechanism. The experiments with histamine and gastrin indicate that reserpine treatment increases the excitability of the parietal cells to these stimuli; those with methacholine and insulin hypoglycemia indicate that reserpine treatment also interferes with the gastrin mechanism.