Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 251-254
- https://doi.org/10.1039/c39870000251
Abstract
The alcohols (7) and (19) and the ketone (28) were treated with diethylaminosulphur trifluoride (DAST) to give the fluoro-compounds (8), (21), and (29) respectively: compound (8) was converted into the potential anti-viral agents carbocyclic-FMAU (14) and carbocyclic-FIAU (16) white compound (21) afforded the 2′-α-fluoro-carbocyclic nucleosides (24), (25), (27), and compound (29) gave the difluoro-analogue (32)[crystal data were obtained on compounds (8) and (9)].Keywords
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