Functional interactions between dendritic cells and NK cells during viral infection
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- 23 December 2002
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 4 (2) , 175-181
- https://doi.org/10.1038/ni880
Abstract
Ly49H+NK1.1+ natural killer (NK) cells are essential for the control of murine cytomegalovirus (MCMV) during the acute stage of infection. This cell subset expands at the later stages of infection in an MCMV-specific fashion. Here we demonstrate a critical interaction between Ly49H+ NK cells and CD8α+ dendritic cells (DCs) whereby the presence of Ly49H+ NK cells results in maintenance of CD8α+ DCs in the spleen during acute MCMV infection. Reciprocally, CD8α+ DCs are essential for the expansion of Ly49H+ NK cells by a mechanism involving interleukin 18 (IL-18) and IL-12. This study provides evidence for a functional interrelationship between DCs and NK cells during viral infection and defines some of the critical cytokines.Keywords
This publication has 44 references indexed in Scilit:
- Reciprocal Activating Interaction between Natural Killer Cells and Dendritic CellsThe Journal of Experimental Medicine, 2002
- Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK CellsThe Journal of Experimental Medicine, 2002
- C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene TranscriptionThe Journal of Experimental Medicine, 2001
- NK cell functions restrain T cell responses during viral infectionsEuropean Journal of Immunology, 2001
- Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49hThe Journal of Experimental Medicine, 2001
- Natural killer cell proliferation induced by anti‐NK1.1 and IL‐2Immunology & Cell Biology, 1998
- Effect of host genotype in determining the relative roles of natural killer cells and T cells in mediating protection against murine cytomegalovirus infectionJournal of General Virology, 1996
- The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.The Journal of Experimental Medicine, 1992
- Genetic control of murine cytomegalovirus infection: Virus titres in resistant and susceptible strains of miceArchiv für die gesamte Virusforschung, 1984
- Role of NK cells in tumour growth and metastasis in beige miceNature, 1980