BONE INVOLVEMENT IN HODGKIN'S DISEASE

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Abstract
Approximately 15 per cent of all patients with Hodgkin's disease will have roentgenographic evidence of cortical bone involvement. Our series shows a 20 per cent incidence, with no predilection regarding sex, age, or pathologic classification. Representative roentgenograms are demonstrated. The most frequent areas involved are the spine and pelvis, and the lesions are usually mixed lytic and blastic. Lesions simulate metastatic malignancies of any kind. Survival curves of 2 previous reports demonstrate an increased survival rate in patients with bone involvement. In our series, the average survival after diagnosis of patients with bone involvement was 4.5 years, and 3.1 years after the onset of bone involvement. The average survival after diagnosis without bone involvement was 3.3 years. We cannot statistically prove with the number of cases in this study that survival is improved in patients with bone involvement, but we can show that at least there is no significant difference in the survival of the 2 groups.

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