The pneumotoxicant paraquat potentiates IL-1 and TNF production by human mononuclear cells
- 1 May 1992
- journal article
- inflammation and-immunomodulation
- Published by Springer Nature in Inflammation Research
- Vol. 36 (1-2) , 66-69
- https://doi.org/10.1007/bf01991230
Abstract
Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. PQ (100 μM) potentiated IL-1 production (2–40 fold) and TNF production (2–18 fold). It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.Keywords
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